29:27 into
the video Marc Lipsitch: “Over 1500 people have contacted the authors
of this paper and then gone to a website and put their names in saying I would
like to be in such a trial and these are thoughtful educated people by and
large who want to do something altruistic. So it is unconventional but I think potentially
very promising. “
Vaccine
testing
Phase 1 is for
safety typically in the 10s of participants
Phase 2 for immunogenicity
10s – 100s participants
Phase 3 for efficacy
and is typically in the 1000s of participants
30:34 “So the idea would be to involve thousands
but not follow them for efficacy, only for safety and immunogenicity which is
quicker, and then do the challenge to evaluate efficacy and then obviously you would need follow up to show the efficacy was
true also in other groups.”
38:20 Howard Bauchner: “Last question, I just made you the pandemic tsar for the next
year, and you have a blank check, well maybe not a blank check, although we
already spent two trillion $, you have a
lot of money, Marc, what are the first three or four or five things you’d want
to do? “
ML: “It’s a
good question. I would invent a time
machine and turn back the clock, so that we could have prepared a little better”
