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Saturday, March 28, 2020

Coronavirus modelers factor in new public health risk: Accusations their work is a hoax

The Washington Post







In the one month since the first U.S. coronavirus death, America has become a country of uncertainty.

New cases of infection and casualties continue multiplying. New York and Louisiana hospitals are grappling with a flood of patients that threatens to overwhelm their health-care systems. Meanwhile, the president and political conservatives are increasingly agitating to end drastic restrictions meant to buy time and save lives.

Running beneath it all, in a continuous loop through our national psyche, are basic questions leaders are struggling to answer: When can we safely lift these quarantines? How many people could die if we do it too early? Just how dangerous will this pandemic turn out to be? And what exactly should be our next step?

This is why epidemiology exists. Its practitioners use math and scientific principles to understand disease, project its consequences, and figure out ways to survive and overcome it. Their models are not meant to be crystal balls predicting exact numbers or dates. They forecast how diseases will spread under different conditions. And their models allow policymakers to foresee challenges, understand trend lines and make the best decisions for the public good.

But one factor many modelers failed to predict was how politicized their work would become in the era of President Trump, and how that in turn could affect their models

In recent days, a growing contingent of Trump supporters have pushed the narrative that health experts are part of a deep-state plot to hurt Trump’s reelection efforts by damaging the economy and keeping the United States shut down as long as possible. Trump himself pushed this idea in the early days of the outbreak, calling warnings on coronavirus a kind of “hoax” meant to undermine him.

The notion is deeply troubling, leading health experts say, because what the country does next and how many people die depend largely on what evidence U.S. leaders and the public use to inform their decisions. Epidemiologists worry their research — intended to avert massive deaths in situations exactly like this pandemic — will be dismissed by federal leaders when it is needed most.


The peak


St. Louis endured two catastrophic episodes during the 1918 flu pandemic. (Library of Congress)




So much of the coming months and our country’s timeline depends on the peak of the coronavirus’s spread — its steepness, length and timing.

But here’s the thing about peaks: You often can’t tell where they are until you’re already past them, on your way down the other side.

And in a country as big as the United States, the peak will be not so much a single curve as it will the sum of many curves — as the outbreak spreads to different cities and regions at different times.

Nonetheless, a new model released Thursday by the University of Washington’s School of Medicine is one of the first to forecast a national peak. It projects that the peak in daily U.S. deaths will arrive in mid-April, and the tail end of that curve, subsiding below 10 daily deaths, will arrive by the first week of June.

But that projection comes with huge caveats because of estimations and assumptions that have to be built into the calculation, given how much is still unknown about the disease covid-19.

The model — created by the university’s Institute for Health Metrics and Evaluation — assumes, for example, that all remaining states that have not enacted strict restrictions on residents will do so in the next week once they see how grave the situation is in areas like New York.

But Florida Gov. Ron DeSantis (R) has refused to issue orders for people to stay at home. Alabama’s governor has similarly resisted. And this week, Mississippi’s governor issued an order defining almost all businesses as “essential” — including auto repair, bars and restaurants.

The Washington model assumes the entire country will maintain these strict restrictions until summer. But Trump has increasingly made clear he wants to reopen parts of the country by Easter on April 12. And on Thursday, Trump unveiled a plan to identify specific counties that he thinks should reopen soon.

The University of Washington model predicts that this first wave of infections will end by summer (with subsequent waves a possibility) and that the death toll during this initial period will range from 38,000 to 162,000 — a lower projection than some earlier models. But the actual death count in coming months will largely depend on how badly hospitals are overwhelmed and whether they receive supplies like ventilators that they desperately need.

On Thursday night, Trump cast doubt on experts’ projections on those as well. “I have a feeling that a lot of the numbers that are being said in some areas are just bigger than they’re going to be,” Trump told Fox News host Sean Hannity in a phone interview. “I don’t believe you need 40,000 or 30,000 ventilators. You know, you go into major hospitals, sometimes they’ll have two ventilators, and now all of a sudden they’re saying, ‘Can we order 30,000 ventilators?’”


On the attack

 
Deborah Birx, White House coronavirus response coordinator, speaks at a Thursday news briefing

The attacks from Trump supporters against epidemiologists ratcheted up several bars on Thursday as pundits on the political right took aim at one of the world’s leading epidemiologists, Neil Ferguson of Imperial College in Britain.

Ferguson had co-written a paper this month estimating 510,000 deaths in England and 2.2 million in the United States — if those countries did not take drastic actions. The paper’s conclusions were so chilling that they launched leaders in both countries into action. The next day, Trump abruptly stopped encouraging Americans to go on with their lives and began urging them instead to work from home and not meet in groups of more than 10.

Since then, Trump has flipped back to wanting workers back at their jobs — framing it as a decision between saving the U.S. economy or a handful of lives. And his supporters have followed, attacking Ferguson online.

After Ferguson gave new testimony to British officials Wednesday, they hailed it as evidence that Ferguson and other experts were overselling the coronavirus threat. Fox News host Laura Ingraham wrongly stated that in his testimony Ferguson’s projection had been “corrected.” The chyron on her show Thursday night stated, “Faulty models may be skewing COVID-19 data.”

“Today — this is what our instinct was — the lead researcher did an about-face on those terrifying projections, the very projections that drove so much of our response,” Ingraham claimed on her show.

A Wall Street Journal columnist wrote that the revision “raises serious questions about the radical countermeasures inspired by public-health experts like Mr. Ferguson.” Even one of Trump’s coronavirus task force coordinator, Deborah Birx, seemed to lean into the questioning of Ferguson. “I’m sure many of you saw the recent report out of the U.K. about them adjusting,” Birx said. “If you remember, that was the report that said there would be 500,000 deaths in the U.K. and 2.2 million deaths in the United States.

They’ve adjusted that number in the U.K. to 20,000. So half a million to 20,000. We’re looking into this in great detail to understand that adjustment.”

But in fact, Ferguson had not revised his projections in his testimony, which he made clear in interviews and Twitter. His earlier study had made clear the estimate of 500,000 deaths in Britain and 2.2 million in the United States projected what could happen if both took absolutely no action against the coronavirus. The new estimate of 20,000 deaths in Britain was a projected result now that Britain had implemented strict restrictions, which this week came to include a full lockdown.

But the argument over models in some ways is beside the point, said Natalie Dean, a biostatistician at the University of Florida. “The models are planning tools, but it doesn’t take a genius to look at what’s happening in Italy and realize that we’re on the same trajectory,” said Dean, who is working on coronavirus vaccine evaluation with the World Health Organization. “That should be enough to tell us we need to be doing more in reaction.”

A warning from pandemics past

One clear warning from epidemiology of past pandemics is the danger of lifting restrictions — as Trump wants to do in two weeks — too soon.

A seminal 2007 paper shows what happened in several U.S. cities when they eased restrictions too soon during the 1918 flu pandemic. Those cities believed they were on the other side of the peak, and, like the United States today, had residents agitating about the economy and for relaxing restrictions.

Once they lifted them, however, the trajectory of those cities soon turned into a double-humped curve with two peaks instead of one.


This chart shows the double-humped peaks of deaths during the 1918 flu in St. Louis. The city imposed strict restrictions early on but loosened them under pressure from its citizens, only to see deaths jump again. (Courtesy of JAMA and Howard Markel)



Two peaks means you get the overwhelmed hospitals, the death and destruction, without that flattening benefit people were trying so hard to achieve with arduous restrictions.

“Knowing when to release the throttle is hard. There’s is no button that says push me now,” said Howard Markel, a historian and physician at the University of Michigan who co-wrote the 2007 paper along with a top CDC official, Martin Cetron. “But the trick is to be patient, not to jump the gun. Otherwise, all that happens is you get more cases, more deaths and everything you worked so hard for with those restrictions just goes to waste.”

One of the perpetual frustrations of trying to prevent disease rather than curing it is that it’s often difficult for the public to appreciate the disasters you help them avoid.

“The problem is there’s no metric for prevention. How many cases you avoid. How many lives you save,” Markel said. “That’s why it’s so hard to stay the course but so important, too.”


Getting reliable information during the pandemic








How do we know which source to trust? It is difficult since we are not epidemiologists. And yet when you come across a reliable source you know it. For me it was the podcast I heard on March 5 and transcribed it on March 11: The Coronavirus Isn't Going Away  


During my 6½ years as a foreign student in the USSR I listened to the BBC World Service, read The Economist and George F. Kennan. After 9/11 for information on Islam I would to turn to Ibn Warraq.  Richard Feynman was there to clarify physics questions.  
As of yesterday here is the site Marc Lipsitch from The Center for Communicable Disease Dynamics announced has become available:  Work on Covid-19 (coronavirus)
Of course, one should never rely on a single source of information, and the maxim audiatur et altera pars should not be forgotten, but this site will with a high degree of probability give you the truth. If something really important pops up I will continue to post it on my blog.

Friday, March 27, 2020

Would you volunteer to get the coronavirus? Someone may have a job for you.




It won’t be pleasant, but it could help prove quickly if a Covid-19 vaccine works.



Mar 25, 2020

A group of academics say that 100 altruistic young people should volunteer to get a vaccine for Covid-19 and then be infected with the coronavirus on purpose.

The idea of such a “challenge trial” is controversial but could speed testing of a vaccine by months, according to a proposal posted online, offering fast evidence that a shot works or doesn’t.

“We need fresh ideas to get out of the #COVID19 dilemma of sacrificing the economy, health care system, or both,” tweeted Marc Lipsitch, a Harvard University epidemiologist who cosigned the proposal with Nir Eyal, a bioethicist at Rutgers University, and Peter Smith, a statistician from the London School of Hygiene & Tropical Medicine.

Some experts believe a vaccine is the best hope to end the epidemic. One candidate created by Moderna Therapeutics of Cambridge, Massachusetts, is already being given to healthy volunteers in Washington state in an initial safety test.

No one, though, has yet had virus squirted up their nose on purpose, something that is ethically dubious under most circumstances. The drawback is obvious, the authors admit: “Challenging volunteers with this live virus risks inducing severe disease and possibly even death.”

Yet the risk could be worth it for society, they think, since trying to infect vaccinated people on purpose might be the quickest way to learn whether a vaccine works.

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One expert in challenge trials, Myron Levine, of the University of Maryland, says he doesn’t believe the idea is merited yet. According to statistics released by the Centers for Disease Control and Prevention, people between 20 and 44 accounted for 20% of those hospitalized for Covid-19 in the US, with about 1 in 750 dying.

“Is this something you would allow your loved one to participate in?” asks Levine. “Ask yourself that.”

Exposing people to a germ can be an acceptable way to do scientific research—and Levine says he’s been doing challenges since 1970, with diseases including cholera. He says the studies are considered permissible in certain scenarios. One is where people get a weakened, or attenuated, version of a virus. Another is if there is a drug cure available in case the vaccine flops and things go south. But there’s no drug treatment yet for the dangerous pneumonia associated with Covid-19.

Despite that, the three authors of the new proposal, none of whom are doctors, say they think that younger adults, who usually don’t suffer serious forms of the illness, could make an informed choice to be the guinea pigs that help save the world from Covid-19. That’s especially true since they might get infected anyway.

The scientific trio offer a sketch of how they think it could be done. First, the youthful volunteers would be subjected to a two-week quarantine to make sure they were virus free. After that, they’d be given the virus and then observed. During the study they would remain isolated in “a secure and comfortable setting.” Doctors could then measure if they had any virus in their throats, and how long it took them to develop any symptoms.

“The required size of such studies would depend upon the endpoints chosen, but they might require of the order of 100 volunteers,” the three speculate. “Any volunteers in whom infection was confirmed would receive excellent care for COVID-19, including priority for any scarce life-saving resources, in state-of-the-art facilities.”

The problem with vaccines is that it typically takes at least 18 months to test them and get supplies ready. And a big chunk of the R&D time is given to a phase 3 trial—the main event, in which hundreds or thousands would get the vaccine and others would not, in an attempt to prove that those who are vaccinated don’t get the disease or have fewer symptoms if they do.

According to Smith, Lipsitch, and Eyal, giving a vaccine to people and then infecting them on purpose could speed up that process and “may be an acceptable way to bypass Phase 3.”

Levine agrees a challenge trial “could cut the time.” However, if Covid-19 continues to afflict the world, the advantage of a contagion study may not be as great as it seems. With lots of people getting infected anyway, a trial that is both speedy and ethical should be possible to organize.

Already, steps are being taken to shrink the time a vaccine will take. Moderna and the National Institutes of Health reportedly began safety studies with its vaccine before finishing the typical animal studies. According to the Boston Globe, Moderna’s CEO, Stéphane Bancel, also told bankers that the company could seek emergency approval from Washington to give its coronavirus vaccine to some people this fall.

“It is possible that under emergency use, a vaccine could be available to some people, possibly including health-care professionals,” Bancel said, according to a filing with the Securities and Exchange Commission.

It’s likely that if a challenge trial occurs, plenty of volunteers would sign up. After all, first responders, EMTs, health-care workers, and even grocery store clerks are already putting themselves at risk of Covid-19 by staying on the job.

“It may seem impermissible to ask people to take on risk of severe illness or death, even for an important collective gain,” the authors of the challenge proposal write. “But we actually ask people to take such risks for others’ direct gain every time we ask volunteer firefighters to rush into burning buildings.”



Marc Lipsitch vs Deborah Birx


Tuesday, March 24, 2020

How South Korea Flattened the Curve




The country showed that it is possible to contain the coronavirus without shutting down the economy, but experts are unsure whether its lessons can work abroad.



Credit...Chung Sung-Jun/Getty Images




By Max Fisher and Choe Sang-Hun





No matter how you look at the numbers, one country stands out from the rest: South Korea.

In late February and early March, the number of new coronavirus infections in the country exploded from a few dozen, to a few hundred, to several thousand.

At the peak, medical workers identified 909 new cases in a single day, Feb. 29, and the country of 50 million people appeared on the verge of being overwhelmed. But less than a week later, the number of new cases halved. Within four days, it halved again — and again the next day.

On Sunday, South Korea reported only 64 new cases, the fewest in nearly a month, even as infections in other countries continue to soar by the thousands daily, devastating health care systems and economies. Italy records several hundred deaths daily; South Korea has not had more than eight in a day.

South Korea is one of only two countries with large outbreaks, alongside China, to flatten the curve of new infections. And it has done so without China’s draconian restrictions on speech and movement, or economically damaging lockdowns like those in Europe and the United States.

As global deaths from the virus surge past 15,000, officials and experts worldwide are scrutinizing South Korea for lessons. And those lessons, while hardly easy, appear relatively straightforward and affordable: swift action, widespread testing and contact tracing, and critical support from citizens.

Yet other hard-hit nations did not follow South Korea’s lead. Some have begun to show interest in emulating its methods — but only after the epidemic had accelerated to the point that they may not be able to control it any time soon.

President Emmanuel Macron of France and Prime Minister Stefan Löfven of Sweden have both called South Korea’s president, Moon Jae-in, to request details on the country’s measures, according to Mr. Moon’s office.

The head of the World Health Organization, Tedros Adhanom Ghebreyesus, has hailed South Korea as demonstrating that containing the virus, while difficult, “can be done.” He urged countries to “apply the lessons learned in Korea and elsewhere.”

South Korean officials caution that their successes are tentative. A risk of resurgence remains, particularly as epidemics continue raging beyond the country’s borders.

Still, Scott Gottlieb, a former commissioner of the Food and Drug Administration, has repeatedly raised South Korea as a model, writing on Twitter, “South Korea is showing Covid-19 can be beat with smart, aggressive public health.”

Lesson 1: Intervene Fast, Before It’s a Crisis


Just one week after the country’s first case was diagnosed in late January, government officials met with representatives from several medical companies. They urged the companies to begin immediately developing coronavirus test kits for mass production, promising emergency approval.

Within two weeks, though South Korea’s confirmed cases remained in the double digits, thousands of test kits were shipping daily. The country now produces 100,000 kits per day, and officials say they are in talks with 17 foreign governments about exporting them.

Officials also swiftly imposed emergency measures in Daegu, a city of 2.5 million where contagion spread fast through a local church.

“South Korea could deal with this without limiting the movement of people because we knew the main source of infection, the church congregation, pretty early on,” said Ki Mo-ran, an epidemiologist advising the government’s coronavirus response. “If we learned about it later than we did, things could have been far worse.”

South Koreans, unlike Europeans and Americans, were also primed to treat the coronavirus as a national emergency, after a 2015 outbreak of Middle East respiratory syndrome in the country killed 38.

The coronavirus is thought to have a five-day incubation period, often followed by a period of mild symptoms that could be mistaken for a cold, when the virus is highly communicable. This pattern creates a lag of a week or two before an outbreak becomes apparent. What looks like a handful of cases can be hundreds; what looks like hundreds can be thousands.

“Such characteristics of the virus render the traditional response, which emphasizes lockdown and isolation, ineffective,” said Kim Gang-lip, South Korea’s vice health minister. “Once it arrives, the old way is not effective in stopping the disease from spreading.”

Lesson 2: Test Early, Often and Safely



South Korea has tested far more people for the coronavirus than any other country, enabling it to isolate and treat many people soon after they are infected

The country has conducted over 300,000 tests, for a per-capita rate more than 40 times that of the United States.

“Testing is central because that leads to early detection, it minimizes further spread and it quickly treats those found with the virus,” Kang Kyung-wha, South Korea’s foreign minister, told the BBC, calling the tests “the key behind our very low fatality rate as well.”

Though South Korea is sometimes portrayed as having averted an epidemic, thousands of people were infected and the government was initially accused of complacency. Its approach to testing was designed to turn back an outbreak already underway.

To spare hospitals and clinics from being overwhelmed, officials opened 600 testing centers designed to screen as many people as possible, as quickly as possible — and keep health workers safe by minimizing contact.

At some walk-in centers, patients enter a chamber resembling a transparent phone booth. Health workers administer throat swabs using thick rubber gloves built into the chamber’s walls.

Relentless public messaging urges South Koreans to seek testing if they or someone they know develop symptoms. Visitors from abroad are required to download a smartphone app that guides them through self-checks for symptoms.

Offices, hotels and other large buildings often use thermal image cameras to identify people with fevers. Many restaurants check customers’ temperatures before accepting them.

Lesson 3: Contact Tracing, Isolation and Surveillance


When someone tests positive, health workers retrace the patient’s recent movements to find, test — and, if necessary, isolate — anyone the person may have had contact with, a process known as contact tracing.

This allows health workers to identify networks of possible transmission early, carving the virus out of society like a surgeon removing a cancer.

South Korea developed tools and practices for aggressive contact tracing during the MERS outbreak. Health officials would retrace patients’ movements using security camera footage, credit card records, even GPS data from their cars and cellphones.

“We did our epidemiological investigations like police detectives,” Dr. Ki said. “Later, we had laws revised to prioritize social security over individual privacy at times of infectious disease crises.”

As the coronavirus outbreak grew too big to track patients so intensively, officials relied more on mass messaging.

South Koreans’ cellphones vibrate with emergency alerts whenever new cases are discovered in their districts. Websites and smartphone apps detail hour-by-hour, sometimes minute-by-minute, timelines of infected people’s travel — which buses they took, when and where they got on and off, even whether they were wearing masks.

People who believe they may have crossed paths with a patient are urged to report to testing centers.

South Koreans have broadly accepted the loss of privacy as a necessary trade-off.

People ordered into self-quarantine must download another app, which alerts officials if a patient ventures out of isolation. Fines for violations can reach $2,500.

By identifying and treating infections early, and segregating mild cases to special centers, South Korea has kept hospitals clear for the most serious patients. Its case fatality rate is just over one percent, among the lowest in the world.

Lesson 4: Enlist The Public’s Help


 There aren’t enough health workers or body-temperature scanners to track everybody, so everyday people must pitch in.

Leaders concluded that subduing the outbreak required keeping citizens fully informed and asking for their cooperation, said Mr. Kim, the vice health minister.

Television broadcasts, subway station announcements and smartphone alerts provide endless reminders to wear face masks, pointers on social distancing and the day’s transmission data.

The messaging instills a near-wartime sense of common purpose. Polls show majority approval for the government’s efforts, with confidence high, panic low and scant hoarding.

“This public trust has resulted in a very high level of civic awareness and voluntary cooperation that strengthens our collective effort,” Lee Tae-ho, the vice minister of foreign affairs, told reporters earlier this month.

Officials also credit the country’s nationalized health care system, which guarantees most care, and special rules covering coronavirus-related costs, as giving even people with no symptoms greater incentive to get tested.

Is The Korean Model Transferable?


 For all the attention to South Korea’s successes, its methods and containment tools are not prohibitively complex or expensive.

Some of the technology the country has used is as simple as specialized rubber gloves and cotton swabs. Of the seven countries with worse outbreaks than South Korea’s, five are richer.

Experts cite three major hurdles to following South Korea’s lead, none related to cost or technology.

One is political will. Many governments have hesitated to impose onerous measures in the absence of a crisis-level outbreak.

Another is public will. Social trust is higher in South Korea than in many other countries, particularly Western democracies beset by polarization and populist backlash.

But time poses the greatest challenge. It may be “too late,” Dr. Ki said, for countries deep into epidemics to control outbreaks as quickly or efficiently as South Korea has.

China turned back the catastrophic first outbreak in Hubei, a province larger than most European countries, though at the cost of shutting down its economy

South Korea’s methods could help the United States, though “we probably lost the chance to have an outcome like South Korea,” Mr. Gottlieb, the former F.D.A. commissioner, wrote on Twitter. “We must do everything to avert the tragic suffering being borne by Italy.”


Max Fisher reported from New York, and Choe Sang-Hun from Seoul, South Korea.

Max Fisher is a London-based international reporter and columnist. He has reported from five continents on conflict, diplomacy, social change and other topics. He co-authors The Interpreter, a column exploring the ideas and context behind major world events. @Max_Fisher  Facebook

Choe Sang-Hun is the Seoul bureau chief for The New York Times, focusing on news on North and South Korea.